Israeli scientists recently published a study in the Journal of Alzheimer’s Disease that suggests that targeting the function of the Apolipoprotein-E (APOE protein) could be a way to revert the disease.
The APOE gene as long been used as a marker for Alzheimer’s disease. It comes in 3 different versions: APOE2, APOE3 and APOE4.
From this list, APOE4 is the one that concerns scientists as it is found in 60 percent of people with a non-familiar form of Alzheimer.
The APOE4 gene produces a version of APOE protein that is less efficient in its function of transporting lipids.
Scientists attempted to overcome this “handicap” by activating the enzymatic complex that loads lipids on APOE. Not only have they showed they could load more lipids on APOE4 proteins, but they also demonstrated that this strategy could revert the effects of Alzheimer in a mouse model.
These results exemplify how some treatments could help subpopulations of patients living with Alzheimer’s disease. That said, this strategy could lead to an interesting outcome.