Hypertension and diabetes, among other cardiovascular risk factors, were shown to not only lead to cerebrovascular and brain atrophic lesions, but have also been associated with neurodegenerative pathologies including Alzheimer's disease.

Moreover, cerebral atherosclerosis and neurodegeneration might in fact use the same biological mechanisms, being oxidative stress, inflammation and deposition of toxic amyloid proteins. These pathologies could also possibly converge with aging to increase the speed at which the brain is damaged.

Therefore, targeting hypertension and diabetes could help to reduce the onset of the disease.